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Soon, a simple blood test to detect cancer
Boston, JAN 5 (AGENCIES):
Published on 6 Jan. 2011 5:19 PM IST
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A blood test so sensitive it can spot a single cancer cell lurking among a billion healthy ones is moving a step closer to being available at your doctor’s office, with potentially revolutionary medical implications. Boston scientists who invented the test and health care giant Johnson & Johnson are joining forces to bring it to market. Four big cancer centres also will start studies using the experimental test this year.
Stray cancer cells in the blood mean that a tumor has spread or is likely to, many doctors believe. A test that can capture such cells has the potential to transform care for many types of cancer, especially breast, prostate, colon and lung. Initially, doctors want to use the test to try to predict what treatments would be best for each patient’s tumor and find out quickly if they are working.
“This is like a liquid biopsy that avoids painful tissue sampling and may give a better way to monitor patients than periodic imaging scans,” said Daniel Haber, chief of Massachusetts General Hospital’s cancer center and one of the test’s inventors. Ultimately, the test may offer a way to screen for cancer besides mammograms, colonoscopies and other lessthan-ideal methods used now.
“There’s a lot of potential here, and that’s why there’s a lot of excitement,” said Mark Kris, lung cancer chief at Memorial Sloan-Kettering Cancer Center in New York. Sloan-Kettering is one of the sites that will study it this year.
Many people have their cancers diagnosed through needle biopsies. These often do not provide enough of a sample to determine what genes or pathways control a tumor’s growth. Or the sample may no longer be available by the time the patient gets sent to a specialist to decide what treatment to prescribe. It is more powerful than CellSearch and traps cells intact. It requires only a couple of teaspoons of blood and can be done repeatedly to monitor treatment.

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